Diagnosis Case Study Example | Topics and Well Written Essays - 750 words

Diagnosis - Case Study ExampleAlong with this, there be anorexia and catabolic process of chronic inflammatory process of the disease. All these may combine to cause profound weight loss over a niggling period of time.3. Since there is a component of malabsorption, Schilling test may be done to rule out Vit B12 deficiency. Electrolytes to rule out potassium, magnesium, and calcium deficiencies quest to be done. Serum albumin would indicate hypoalbuminaemia indicating amino acid malabosrption or protein losing enteropathy. Air-contrast barium enema and CT scan need to be done to damp delineate the terminal ileal involvement. Colonoscopic examination with rectal biopsy can yield the histologic nature of the disease.4. Apart from other general measures like nothing orally, intravenous alimentation, melted resuscitation, the medical therapy of first choice would have been sulfasalazine. This drug consists of a sulfapyridine moiety chemically bound to 5-aminosalicylate. This undergoe s bacterial cleavage, the liberated sulfapyridine is absorbed, and the salicylate component exerts its anti-inflammatory action by dint of inhibition of prostaglandin synthesis, thus passingucing the inflammation.5. 5. The complications that may arise out of this disease, that is, Crohns disease are intestinal obstruction fistula formation with contiguous intestinal lumen or urinary bundle small-bowel or colonic malignancy bile salt malabsorption leading to increased gall stones and increased incidence of urinary tract oxalate stones.6. If there is associated chronic inflammation of the bone marrow, there may be anemia with decrease in the platelet count. The anaemia is versatile, so are the red cell indices. Megaloblastic anemia with increased MCV is rare.7. On the basis of these preliminary tests, the diagnosis would be Crohns disease. This disease presents in a young adult with variable weight loss, right lower quadrant discomfort or pain, and diarrhoea. The diarrhoea is usu ally moderate often without gross blood. The patient looked pale due to anaemia, and rima oris ulcerations were due to aphthous stomatitis, which is a common accompaniment. The right lower quadrant tenderness is consistent with the mass felt per abdomen that reflected adherent loops of bowel. As expected, the blood visualize reflected anaemia and leukocytosis. The final diagnosis is made from the appearance of the distal ileum that showed narrowing and thickening of the intestinal wall.8. The main jeopardy factor is genetic predisposition to the using of the disease. Whites and Jews have increased incidences, and increased preponderance of disease in monozygotic twins support. Exact genetic linkage yet to be discovered.9. The other risk factors that may be involved are, immune mechanism suggested by extra-intestinal manifestations, abnormalities of cell-mediated immunity, and psychological factors caused by stress.10. There is considerable individual variation with respect to dr ug metabolism, and so effects of the drug. Drug metabolism is related to cytochrome P450 family of genes. In humans, enzymes encoded by P450 genes are located in the liver where they metabolize drugs. Through oxidative metabolism, these enhance water system solubility of the drug to enhance its excretion. For drugs that are metabolized in this way, this process affects the blood levels of the compound, so the therapeutic efficacy, and sometimes, this is necessary to